MyBioSource.com's ITGAV Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The ITGAV Antibody was generated using CD51, Integrin Alpha V, Integrin alphaV, and Integrin alphaVbeta3 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1, 2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1, 2). Several alphaV subfamily members, including alphaVbeta3, alphaVbeta5, alphaVbeta1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on alphaV integrin as a key therapeutic target in the treatment of cancer (10-12)